楊蜀嵐未知
中山大學附屬第一醫院轉化醫學研究中心
醫療/科研特長(限400字內)： 應用斑馬魚為模式生物研究與人類重要疾病相關基因的功能。團隊目前已構建并獲得多個重要人類疾病相關基因的斑馬魚敲除品系以及誘導型過表達轉基因斑馬魚品系，并對其生物學功能進行了初步研究，結合臨床樣本和其他生物模型，進一步探索這些基因的異常表達導致疾病發生的分子機制。 研究方向：人類疾病相關易感基因的致病機制研究 主要教育和工作經歷： 2000年12月獲農學博士學位。2001年到2011年期間，先后在新加坡分子和細胞生物學研究院(IMCB)從事博士后研究和擔任研究員、資深研究員工作，主要以模式生物擬南芥、斑馬魚為研究對象，研究機體器官發育的分子機理。2011年12月，作為中山大學“百人計劃”引進人才到本院工作，建立了斑馬魚疾病模式動物公共平臺，開展人類疾病相關易感基因的致病機制研究，并與其他相關科室合作，共同促進基礎與臨床相結合的轉化醫學研究。 論著： 1.Tong Fang#, Zhang Mingming, Guo Xiaoling, Hongshun Shi, Guan Wen , Wang Haihe* and Yang Shulan*. Expression patterns of SH3BGR family members in zebrafish development. Development Genes and Evolution 2016, 226(4): 287-295. 2.Zhang Wenliang#, Shi Hongshun#, Zhang Mingming, Liu Bin, Mao Shuai, Li Li, Tong Fang, Liu Guoliang, Yang Shulan*., and Wang Haihe*. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. International Journal of Biochemistry and Cell Biology. 2016, 73: 127-136. 3.Li Li#, Shi Hongshun#, Zhang Mingming, Guo Xiaoling, Tong Fang, Zhang Wenliang, Zhou Junyi, Wang Haihe*, Yang Shulan*. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology, 2016, 48(4):1541-1552. 4.Qu Shuang#, Liu Bin, Guo Xiaoling, Shi Hongshun, Zhou Meifeng, Li Li, Yang Shulan, Tong Xiuzhen*, and Wang,Haihe*.Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD–negative acute myeloid leukemia Cancer. 2014, 120(14): 2130-2141. 5.Yang Shu-Lan#,, Aw Sharon Siqi, Chang Qingchang, Korzh Svetlana, Korzh Vladimir*,and Peng Jinrong*. Depletion of Bhmt elevates sonic hedgehog transcript levels to promote pancreatic islet development in zebrafish, Endocrinology, 2011: 152(12):4706-4717. 6.Korzh Svetlana, Winata Cecilia L, Zheng Weiling, Yang Shulan, Ao Yin, Philip Ingham, Zhiyuan Gong*. The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development. Developmental Biology, 2011,359：262–276. 7.Ma Hongli#, Zhang Shubiao, Ji Lan, Zhu Hongbo, Yang Shulan, Fang Xuanjun and Yang Rencui. Mapping and in silico isolation of the EUI1 gene controlling upper internode elongation in rice. Plant Molecular Biology, 2006, 60: 87-94 8.Yang Shu-Lan#, Puah Ching San, Xie Li-Fen, Jiang Lixi, Zhang Xue-Qin, Chen Li-Qun, Ye De. Over-expression of TPD1 alters the cell fates in the arabidopsis carpel and tapetum via genetic Interaction with EMS1/EXS. Plant Physiology, 2005, 139: 186-191. 9.Jiang Li-Xi#, Yang Shu-Lan#, Xie Li-Fen, Puah Ching San, Yang Wei-Cai, Sundaresan Venkatesan and Ye De. VANGUARD1 encodes a pectin methylesterase that enhances pollen tube growth in the Arabidopsis style and transmitting tract. Plant Cell, 2005, 17: 584-596. (Faculty of 1000 推薦). 10.Yang Shu-Lan#, Xie Li-Fen, Mao Hui-Zhu, Puah CS, Yang Wei Cai, Jiang Lix, Ye De. 2003. Tapetum determinant 1 gene is required for cell specialization in the Arabidopsis anther. Plant Cell, 15: 2792-2804. (Faculty of 1000推薦).
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